Molecularly Imprinted Polymeric Nanoparticles by Precipitation Polymerization and Characterization by Quantitative NMR Spectroscopy

Title: Molecularly Imprinted Polymeric Nanoparticles by Precipitation Polymerization and Characterization by Quantitative NMR Spectroscopy
Creator: Holdsworth, Clovia I.; Lim, K. Fremielle; Muang-Non, Phonlakrit
Relation: Methods in Molecular Biology 2359
Publisher Link: http://dx.doi.org/10.1007/978-1-0716-1629-1_2
Publisher: Humana
Resource Type: book chapter
Date: 2021
Description: An optimized synthetic methodology for the preparation of highly homogeneous MIP nanoparticles by the precipitation method is presented. A quantitative 1H NMR method that was developed to estimate template incorporation, polymer composition and conversion, and binding capacities and selectivities is also described. While the experiment presented here is exemplified by an MIP formulation using (±)-propranolol as the template, methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the crosslinker, the methods and techniques are applicable to other precipitation MIP systems.
Subject: precipitation MIP; MIP microspheres; MIP nanospheres; q-NMR; propranolol MIP; q-NMR analysis of propranolol
Identifier: http://hdl.handle.net/1959.13/1450578
Identifier: uon:43970
Identifier: ISBN:9781071616284
Language: eng